New approach to FAK pathway/collaboration teams

Date: January 31, 2015
Source: University of Colorado
The study collaborates with Kufa and Al-Muthanna Universities/Iraq overseas.  

Researchers have try to discovered a new cell signaling pathway of FAK that controls cell growth and development, a pathway that, when defective, helps promote the formation of several major forms of human cancer, and inflammatory response.

The new pathway, part of a global DNA damage response, turns off many genes, including some that have are known to cause cancer because, unchecked, they can promote aberrant cell division. “It’s important to make sure this pathway works correctly, because it involve in cells from dividing excessively” said Nasser G. Yousif, a professor of medical oncology/hematology and laboratory medicine, Denver Cancer Center research and senior lecturer, Al-Muthanna University/Medical school. “When this pathway is defective, cancers can happen.”

“Our research points to a new regulatory role for FAK, and also presents an exciting new therapeutic target for suppressing canonical FAK signaling to treat or prevent cancer,” said Douglas Hainz, professor of chemistry at Colorado and principal investigator of the research. Additionally, new therapies that target the pathway could be developed to correct newly identified defects, thereby blocking the formation of cancer.

The study is funded by the National Institutes of Health and the BioMedicine Society.

Research TeamProf.  Douglas Hainz, MD, PhD Team
               Colorado University
1st line/Left side: Ana Gabrila, Suzan Lang, Noemi Schwulst, Emily Rotllan
2nd line/left side: Bimonte Sieri, Prof. Douglas Hainz, and Freeman Nelson
Main study: Animal model/aging mice
Septic shock, Renal Injury, Ovarian cancer cell
Prof. Nasser G. Yousif, MD, MSc, PhDResearch team 2 Team
            Kufa/Al-Muthanna Universities
Left side: Kerar K. Jaen, Ali A. Aldelimy, prof. Najah R. Hadi/Chief  department of Pharmacology and Therapeutics/Kufa University, Prof. N Yousif, Sahar M. Alhar, Fada A Ghafil
Main study: Animal model/adult mice
                       Septic shock
                       Renal Injury
                      Ovarian cancer cell


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